山蜡梅化学成分研究

张鹏耀,舒任庚,严喜鸾,伍庆华

中国药学杂志 ›› 2017, Vol. 52 ›› Issue (18) : 1594-1596.

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中国药学杂志 ›› 2017, Vol. 52 ›› Issue (18) : 1594-1596. DOI: 10.11669/cpj.2017.18.007
论著

山蜡梅化学成分研究

  • 张鹏耀1,舒任庚1*,严喜鸾2,伍庆华1
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Chemical Constituents of Chimonanthus nitens Oliv.

  • ZHANG Peng-yao1, SHU Ren-geng1*, YAN Xi-luan2, WU Qing-hua1
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摘要

目的 研究江西道地药材山蜡梅(Chimonanthus nitens Oliv.)叶的化学成分。方法 利用硅胶柱色谱、Sephadex LH-20 柱色谱、反相硅胶柱色谱及半制备高效液相色谱等多种方法对山蜡梅叶提取物进行分离纯化,通过理化常数测定、光谱数据分析鉴定化合物结构。结果 从山蜡梅叶中分离得到10 个化合物,分别鉴定为:尿嘧啶(1),6,7-二甲氧基香豆素(2),6, 7, 8-三甲氧基香豆素(3),对羟基苯甲酸乙酯(4),两个非对映异构体(3RS, 6RS)-2, 6-二甲基-3, 6-二羟基-1, 7-辛二烯(5 和6),山柰酚(7),异嗪皮啶(8),东莨菪内酯(9)和地芰普内酯(10)。结论 化合物1、3~6和10为首次从该植物中分离得到,化合物1、4~6 为首次从该属植物中分离得到。

Abstract

OBJECTIVE To study the chemical constituents from the leaves of Jiangxi genuine medicinal material Chimonanthus nitens Oliv. METHODS The compounds were isolated and purified by silica gel column chromatography, Sephadex LH-20, ODS column chromatography, semi-preparative HPLC, and so on. Their structures were elucidated on the basis of physiochemical properties and spectral data. RESULTS Ten compounds were isolated and elucidated as uracil (1), 6,7-dimethoxycoumarin (2), 6,7,8-trimethoxycoumarin (3), p-hydroxybenzoic acid ethyl ester (4), 1∶1 mixture of two diastereomers identical with (3RS,6RS)-2, 6-dimethyl-octa-1,7-dien-3,6-diol (5 and 6), kaempferol (7), isofraxidin (8), scopoletin (9), and loliolide (10). CONCLUSION Compounds 1, 3-6 and 10 are isolated from this plant for the first time and compounds 1, 4-6 are isolated from this genus for the first time.

关键词

山蜡梅 / (3RS / 6RS)-2 / 6-二甲基-3 / 6-二羟基-1 / 7-辛二烯 / 对羟基苯甲酸乙酯 / 6 / 7 / 8-三甲氧基香豆素 / 东莨菪内酯

Key words

Chimonanthus nitens Oliv. / (3RS,6RS)-2,6-dimethylocta-1,7-diene-3,6-diol / p-hydroxybenzoic acid ethyl ester / 6,7,8-trimethoxycoumarin / scopoletin

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张鹏耀,舒任庚,严喜鸾,伍庆华. 山蜡梅化学成分研究[J]. 中国药学杂志, 2017, 52(18): 1594-1596 https://doi.org/10.11669/cpj.2017.18.007
ZHANG Peng-yao, SHU Ren-geng, YAN Xi-luan, WU Qing-hua. Chemical Constituents of Chimonanthus nitens Oliv.[J]. Chinese Pharmaceutical Journal, 2017, 52(18): 1594-1596 https://doi.org/10.11669/cpj.2017.18.007
中图分类号: R284   

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基金

国家自然科学基金资助项目(81360631)
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